Multidisciplinary Journal of Science and Technology

SYNTHESIS AND DEVELOPMENT HISTORY OF 1,2,3-TRIAZOLES

Zakirjonova Diyora

Andijon davlat pegadogika instituti kimyo yo‘nalishi 2 kurs magistranti

Kirg‘izov Fazlidin

Andijon davlat pedagogika instituti Kimyo kafedrasi dotsenti k.f.f.d (PhD)

Keywords: 1,2,3-triazole; Huisgen cycloaddition; click chemistry; CuAAC; regioselectivity; azide; alkyne

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Abstract

1,2,3-Triazoles are robust, functionally rich heterocycles. This paper reviews the history and methodology of Huisgen 1,3-dipolar cycloaddition, the click chemistry concept, and Cu(I)-catalyzed azide–alkyne cycloaddition. Reaction conditions, regioselectivity, and applications are discussed, with comparative notes to Uzbek and Russian sources.

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