Multidisciplinary Journal of Science and Technology

CORRECTION OF HEAVY METAL INTOXICATION WITH BIOACTIVE SUBSTANCES EXTRACTED FROM PLANTS

Shakarova Shaxnoza

Islom Karimov nomidagi Toshkent davlat texnika universiteti .

Keywords: og’ir metallar, intoksikasiya, fitokorreksiya, pektin, flavonoidlar, glisirrizin, antioksidant himoya, enterosorbsiya, o’simlik biofaol moddalari, organoproteksiya

---

Abstract

This review article analyzes the pathogenetic basis of intoxication with heavy metals, especially lead and cadmium, and the possibilities of its correction using bioactive substances obtained from plants. The analysis of the literature shows that the leading mechanisms that cause the toxic effects of heavy metals include oxidative stress, lipid peroxidation, mitochondrial dysfunction, activation of inflammatory mediators, and apoptosis. In this regard, plant-derived pectins, flavonoids, polyphenols, glycyrrhizin, proanthocyanidins, and other phytocomponents are of particular importance due to their sorption, antioxidant, membrane-stabilizing, and organoprotective properties. The article highlights the work of Uzbek researchers on the example of licorice (Glycyrrhiza glabra), citrus raw materials, grape seed and grape seed oil, hawthorn fruit pectins, as well as the need to control the heavy metal content and element content of medicinal plant raw materials. In conclusion, it was noted that plant bioactive substances have the greatest practical value not as the main antidote in the treatment of heavy metal intoxication, but as a pathogenetically based adjuvant correction agent.

---

References

1. World Health Organization. Lead poisoning and health. - Geneva: WHO, 2024.

2. World Health Organization. Cadmium: chemicals of public concern. - Geneva: WHO, 2022.

3. Jandosov J., Alavijeh M., Sultakhan S. et al. Activated Carbon/Pectin Composite Enterosorbent for Human Protection from Intoxication with Xenobiotics Pb(II) and Sodium Diclofenac // Molecules. - 2022. - Vol. 27, № 7. - Art. 2296.

4. Kim S.C., Byun S.H., Yang C.H., Kim C.Y., Kim J.W., Kim S.G. Cytoprotective effects of Glycyrrhizae radix extract and its active component liquiritigenin against cadmium-induced toxicity // Toxicology. - 2004. - Vol. 197. - P. 239-251.

5. Lee J.R. Hepatoprotective Activity of Licorice Water Extract against Cadmium-induced Toxicity in Rats // Evidence-Based Complementary and Alternative Medicine. - 2009. - Vol. 6, № 2. - P. 195-201.

6. Omar E.M., El-Sayed L.M., Abdelmeguid N.E. Reversal Effects of Royal Jelly and Propolis Against Cadmium-Induced Hepatorenal Toxicity in Rats // Biological Trace Element Research. - 2024. - Vol. 202. - P. 1612-1627.

7. Karomatov I.D. Solodka, lakrichnik, lakrisa - primenenie v medisine (obzor literaturы) // Aktualnыe problemы gumanitarnыx i estestvennыx nauk. - 2013. - № 11(58). - S. 230-235.

8. Karomatov I.D., Abduvoxidov A.T. Lechebnыe svoystva kostochek vinograda i vinogradnogo masla (obzor literaturы) // Biologiya i integrativnaya medisina. - 2018. - № 1(18). - S. 49-86.

9. Karomatov I.D., Kayimova D.I. Sitrusovыe kak lechebnыe sredstva // Biologiya i integrativnaya medisina. - 2019. - № 12(40). - S. 50-108.

10. Karomatov I.D., Takayeva SH.K. Antitoksicheskie svoystva propolisa // Biologiya i integrativnaya medisina. - 2020. - № 3(43). - S. 124-136.

11. Zokirova M.S., Malikova M.X., Botirov E.X. Pektinovыe veщestva plodov dvux vidov boyarыshnika, proizrastayuщix v Uzbekistane // Ximiya rastitelnogo sыrya. - 2024. - № 2. - S. 118-125.

12. Turdaliyeva P.K. Sozdanie lechebnogo rastitelnogo sbora iz lekarstvennыx rasteniy Ferganskoy dolinы na osnove elementnogo sostava dlya profilaktiki i lecheniya zabolevaniy serdechno-sosudistoy sistemы // Ximiya rastitelnogo sыrya. - 2024. - № 4. - S. 241-249.

13. Amonov M.A., Abduraxmanov B.A., Sotimov G.B., Xalilov R.M., Matchanov A.D. Soderjanie tyajelыx metallov, makro-mikroelementov v nadzemnыx i podzemnыx organax Acorus calamus, proizrastayuщego v Uzbekistane // Universum: texnicheskie nauki. - 2022. - № 2(95).

14. Igamberdiyeva P.K., Mamadjanov B.S., Saidaxmadova N.G. Issledovanie kolichestva mikroelementov lekarstvennыx rasteniy Yujnoy Ferganы i perspektivы ix primeneniya pri lechenii jelezodefisitnoy anemii // Sovremennaya medisina: aktualnыe voprosы. - 2015. - № 44. - S. 80-87.

15.