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Published
2025-12-01
Section
Articles
How to Cite
How to Cite
CHANGES IN THE ACTIVITY OF SMALL INTESTINAL DISACCHARIDASES IN DIABETES MELLITUS
Shohsanam Olimova
,Department of Normal and Pathological Physiology, Andijan Branch of Kokand University
Azizaxon Mazalova
Department of Normal and Pathological Physiology, Andijan Branch of Kokand University
Marvarida Sobirova
Department of Normal and Pathological Physiology, Andijan Branch of Kokand University
Keywords: Diabetes mellitus, small intestine, disaccharidases, lactase, sucrase, maltase, disaccharidase deficiency, hyperglycemia.
Abstract
Diabetes mellitus (DM) is a chronic metabolic disease associated with insufficient insulin secretion or impaired insulin action. DM not only disrupts the metabolism of carbohydrates, fats, and proteins but also seriously affects the function of the digestive system. The aim of this article is to study the mechanisms and clinical significance of decreased activity of key disaccharidase enzymes (lactase, sucrase, maltase) located in the small intestine of patients with DM. Research results indicate that hyperglycemia, oxidative stress, and tissue insulin resistance lead to morphological and functional impairments of the small intestinal epithelium, which causes a decrease in enzyme activity and, consequently, impaired digestion of disaccharides (disaccharidase deficiency). This condition leads to the exacerbation of gastrointestinal symptoms such as abdominal pain, diarrhea, and flatulence in patients.
References
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