Multidisciplinary Journal of Science and Technology

IMPROVEMENT OF IMMUNOHEMATOLOGICAL CHARACTERISTICS AND PROPHYLAXIS OF COMORBID HEMORRHAGIC VASCULITIS AND NEPHROPATHY IN CHILDREN

Mamadaliyeva Hilolaxon

Andijon davlat tibbiyot instituti Gospital pediatriya kafedrasi assistenti

Keywords: hemorrhagic vasculitis, nephropathy, children, immune system, hematology, prevention, comorbidity

---

Abstract

The comorbid course of hemorrhagic vasculitis (Henoch–Schönlein purpura) and nephropathy in children is associated with more severe clinical manifestations and profound immune-hematological disturbances. The study investigated immune and hematological parameters (IgA, IgG, IgM, CD4+/CD8+ ratio, complement C3, and blood indices). Results revealed elevated IgA levels, activation of the complement system, and a reduced CD4+/CD8+ ratio. The improved preventive program — including immunomodulatory therapy and long-term follow-up — reduced relapse frequency and preserved renal function in affected children.

---

References

1. Mamadaliyeva Hilolaxon Olimjon qizi Immuno-hematological features of the course of hemorrhagic vasculitis in children with nephropathy and improvement of prevention International journal of medical sciences ISSN 2692-5206. 2025 4-son.

2. Mamadaliyeva Hilolaxon Olimjon kizi. IMMUNE-HEMATOLOGICAL FEATURES OF NEPHROPATHY COMPLICATIONS IN PATIENTS WITH HEMORRHAGIC VASCULITIS JOURNAL OF SCIENCE-INNOVATIVE RESEARCH IN UZBEKISTAN (ISSN: 2992-8869) 2024.

3. O‘rinboyeva D., Tursunov A. Pediatrik gemorragik vaskulit va uning buyrak bilan kechishi. Andijon: Andijon Davlat Tibbiyot Instituti Nashriyoti, 2022. 112–118 b.

4. Smith K., Jones L. Henoch-Schönlein purpura nephritis in children: immunopathogenesis and management. Pediatric Nephrology, 2021; 36: 2335–2346.

5. Lee S.H., Kim H.J. Immune complex-mediated vasculitis in pediatric patients: diagnostic approaches. Clinical Immunology, 2020; 214: 108384.

6. Xu J., Chen Y., Wang X. The role of IgA and complement in childhood Henoch-Schönlein purpura nephritis. Frontiers in Pediatrics, 2022; 10: 813245.

7. Makhmudov R., Rustamov Z. Pediatrik nefropatiyada profilaktika va davolash yondashuvlari. Tibbiyot va Sog‘liq, 2023; 5(1): 45–53.

8. He Y., Li W., Zhang J. T-cell imbalance in children with vasculitis and renal involvement. Journal of Pediatric Immunology, 2021; 13(2): 77–85.

9. Kim J., Park S. Thrombocytosis and inflammatory markers in pediatric vasculitis. International Journal of Pediatric Hematology, 2020; 14: 112–120.

10. World Health Organization. Clinical guidelines for pediatric vasculitis. Geneva: WHO, 2023.

11. Zubair M., Khan R. Immunomodulatory therapy in childhood vasculitis. Pediatrics International, 2022; 64(9): e15321.