PDF
ZENODO
Published
2025-11-05
Section
Articles
How to Cite
How to Cite
RENAL EFFECTS OF MUMIYO: ENHANCEMENT OF DIURESIS AND NATRIURESIS IN EXPERIMENTAL RATS
Rizakova Dilorom
Andijan State Medical Institute, Department of Pharmacology, Clinical Pharmacology, and Medical Biotechnology.
Keywords: mumiyo; shilajit; diuresis; natriuresis; sodium excretion; water–salt balance; renal function; experimental rats.
Abstract
Mumiyo (shilajit) is a natural herbo-mineral substance long used in traditional medicine for its restorative properties. This study investigated the effect of mumiyo on water and sodium excretion in rats. Adult male rats (180–220 g) were divided into control and experimental groups (n = 10 each). The experimental group received mumiyo orally at 50 mg/kg for seven days. Water and salt loading tests were performed, and urine was collected for 4 hours. Mumiyo treatment significantly increased urine volume and sodium excretion compared with controls (P < 0.05). After salt loading, the natriuretic response was particularly pronounced. These findings indicate that mumiyo enhances renal excretory function by promoting diuresis and natriuresis, supporting its traditional use in maintaining fluid and electrolyte balance.
References
1. Qi Z, Kelley E. The WHO Traditional Medicine Strategy 2014-2023: A perspective. Science. 2014;346:S5-S6.
2. “WHO Traditional Medicine Strategy 2014-2023”. World Health Organization Retrieved 2014-04-20. 2013.
3. Ghosal S. 2006. Shilajit in Perspective. Narosa Publishing House, New Delhi India.
4. Olivieri MF, Marzari F, Kesel AJ, Bonalume L, Saettini F. Pharmacology and psychiatry at the origins of Greek medicine: The myth of Melampus and the madness of the Proetides. J Hist Neurosci. 2017;26(2):193-215.
5. Wilson E, Rajamanickam GV, Dubey GP,et al.2011. Review on shilajit used in traditional Indian medicine.J Ethnopharmacol 136:1–9
6. Schepetkin I, Khebnikov A, Kwon BS. 2002. Medical drugs from humus matter: focus on mumie.Drug Devel Res57: 140–159
7. Shirbeigi L ZA, Naghizadeh A, Alizadeh Vaghasloo M. The Concept of Temperaments in Traditional Persian Medicine. Trad Integr Med. 2017;2(3):143-56.
8. Frolova N, Kiseleva L, Tatiana. Chemical composition of mumijo and methods for determining its authenticity and quality (a review). Pharma Chem J. 1996;30(8):543-7.
9. Agarwal SP, Khanna R, Karmarkar R, Anwer MK, Khar RK. Shilajit: a review. Phytother Res. 2007;21(5):401-5.
10. Verma A, Kumar N, Gupta L, Chaudhary S. Shilajitin Cancer Treatment: Probable Mode of Action. Int J Pharmaceutic Bio Arch. 2016;7(1):12-6.
11. Stohs SJ, Singh K, Das A, Roy S, Sen CK. 12-Energy and Health Benefits of Shilajit. In: Bagchi D, editor. Sustained Energy for Enhanced Human Functions and Activity. Academic Press; 2017. p. 187-204
12. Ghosal S, Lal J, Singh SK, Goel RK, Jaiswal AK, Bhattacharya SK. The need for formulation of Shilajit by its isolated active constituents. Phytother Res. 1991;5(5):211-6
13. Trivedi N, Mazumdar B, Bhatt J, Hemavathi K. Effect of shilajit on blood glucose and lipid profile in alloxaninduced diabetic rats. Indian J Pharmacol. 2004;36(6):373-6.
