PDF
ZENODO
Published
2025-11-05
Section
Articles
How to Cite
How to Cite
EFFECT OF DIFFERENT DOSES OF MUMIYO ON DIURETIC RESPONSE IN DOGS FOLLOWING INTRAVENOUS ADMINISTRATION
Boltabaeva Dilbarkhon
Senior Teacher of Andijan State Medical Institute, Department of Pharmacology, Clinical Pharmacology, and Medical Biotechnology
Keywords: Mumiyo; Shilajit; diuresis; natriuresis; traditional medicine; Khamzaabad mumiyo; intravenous administration; renal function; water–electrolyte balance; adaptogenic compounds
Abstract
Mumiyo (Shilajit) is a natural herbo-mineral compound long used in traditional medicine for its rejuvenating and adaptogenic effects. This study aimed to evaluate the diuretic activity of Khamzaabad mumiyo in dogs following intravenous administration. Experiments were conducted under controlled conditions, and urine samples were collected hourly for five hours. Mumiyo was administered intravenously at doses of 1–50 mg/kg in 0.9% saline solution. The results showed a clear, dose-dependent increase in urine output and electrolyte excretion, beginning one hour after injection and lasting up to four hours. The diuretic action was primarily associated with reduced tubular reabsorption and enhanced renal excretion of water, sodium, and potassium. These findings suggest that Khamzaabad mumiyo exhibits significant diuretic and natriuretic properties and may be useful for identifying and standardizing Central Asian mumiyo preparations.
References
1. Qi Z, Kelley E. The WHO Traditional Medicine Strategy 2014-2023: A perspective. Science. 2014;346:S5-S6.
2. “WHO Traditional Medicine Strategy 2014-2023”. World Health Organization Retrieved 2014-04-20. 2013.
3. Ghosal S. 2006. Shilajit in Perspective. Narosa Publishing House, New Delhi India.
4. Olivieri MF, Marzari F, Kesel AJ, Bonalume L, Saettini F. Pharmacology and psychiatry at the origins of Greek medicine: The myth of Melampus and the madness of the Proetides. J Hist Neurosci. 2017;26(2):193-215.
5. Wilson E, Rajamanickam GV, Dubey GP,et al.2011. Review on shilajit used in traditional Indian medicine.J Ethnopharmacol 136:1–9
6. Schepetkin I, Khebnikov A, Kwon BS. 2002. Medical drugs from humus matter: focus on mumie.Drug Devel Res57: 140–159
7. Shirbeigi L ZA, Naghizadeh A, Alizadeh Vaghasloo M. The Concept of Temperaments in Traditional Persian Medicine. Trad Integr Med. 2017;2(3):143-56.
8. Frolova N, Kiseleva L, Tatiana. Chemical composition of mumijo and methods for determining its authenticity and quality (a review). Pharma Chem J. 1996;30(8):543-7.
9. Agarwal SP, Khanna R, Karmarkar R, Anwer MK, Khar RK. Shilajit: a review. Phytother Res. 2007;21(5):401-5.
10. Verma A, Kumar N, Gupta L, Chaudhary S. Shilajitin Cancer Treatment: Probable Mode of Action. Int J Pharmaceutic Bio Arch. 2016;7(1):12-6.
11. Stohs SJ, Singh K, Das A, Roy S, Sen CK. 12-Energy and Health Benefits of Shilajit. In: Bagchi D, editor. Sustained Energy for Enhanced Human Functions and Activity. Academic Press; 2017. p. 187-204
12. Ghosal S, Lal J, Singh SK, Goel RK, Jaiswal AK, Bhattacharya SK. The need for formulation of Shilajit by its isolated active constituents. Phytother Res. 1991;5(5):211-6
13. Trivedi N, Mazumdar B, Bhatt J, Hemavathi K. Effect of shilajit on blood glucose and lipid profile in alloxaninduced diabetic rats. Indian J Pharmacol. 2004;36(6):373-6.
