PDF
ZENODO
Published
2025-05-29
Section
Articles
How to Cite
How to Cite
SPECIFIC CHARACTERISTICS OF QUANTITATIVE CHANGES IN EXTRACELLULAR MATRIX COMPONENTS IN CHRONIC TOXIC LIVER INJURY
Turayev Shahkboz
Hayitov Maqsud Samadovich
Keywords: Chronic toxic damage, liver, extracellular matrix, collagen, fibrosis, morphology.
Abstract
This article presents an analysis of scientific sources regarding the quantitative changes of extracellular matrix components in liver tissue under chronic toxic damage. According to the research findings, prolonged exposure to toxic agents increases the levels of collagen, fibronectin, laminin, and proteoglycans, leading to the early development of liver fibrosis. The literature review serves as an important source for a deeper understanding of the morphological basis of liver injury, early diagnosis, and the development of effective therapeutic approaches.
References
1. Zvyagintseva N.P. va boshq. "Toksik gepatitda kollagen strukturalarining dinamikasi". Eksperimentalnaya Patologiya, 2003.
2. Kiryushchenko A.B. "Fibronektin va lamininning jigar toksik zararlanishidagi roli". Vestnik Morfologii, 2009.
3. Pashkov V.V., Timoshenko A.I. "HAM komponentlarining ultrastrukturasidagi o‘zgarishlar". Morfologiya, 2015.
4. Khayrutdinov S.Yu. "Proteoglikanlar va toksik gepatopatiya". Biomeditsinskiy Zhurnal, 2020.
5. Harvard Medical School, Hepatology Research Group. "Hepatic Stellate Cells in Toxic Liver Injury". Hepatology Journal, 2021.
6. Zulfiya, D. (2022). SOG ‘LOM TURMUSH TARZINI SHAKLLANTIRISHDA SOG ‘LOMLASHTIRUVCI TEXNOLOGIYALAR. Новости образования: исследование в XXI веке, 1(5), 697-700.
7. Нарметова, Ю., & Дехкамбаева, З. (2024). ВЛИЯНИЕ НЕРЕШЁННЫХ ПСИХОЛОГИЧЕСКИХ КОНФЛИКТОВ И АЛЕКСИТИМИИ НА СОМАТИЧЕСКОЕ ЗДОРОВЬЕ.Multidisciplinary Journal of Science and Technology,4(12), 97-99.
8. .Мелибаева, Р. (2019). Использование обобщенных способов учебной деятельности-фактор совершенствования творческого мышления.
9. .Мелибаева, Р. Н. (2019). Талабалар тафаккурини ривожлантиришда укув машгулотларининг урни. PSIXOLOGIYA Учредители: Бухарский государственный университет, (2), 35-40.
10. Dekhkambaeva Zulfia (20025) ANALYSIS OF CONCEPTS OF DEVELOPING THE CREATIVE ABILITY OF STUDENTS IN HIGHER EDUCATIONAL INSTITUTIONS. (2025). EduVision: Journal of Innovations in Pedagogy and Educational Advancements, 1(2), 292-296.
