AGE-RELATED CHANGES IN THE VASCULAR NETWORKS OF THE LATERAL VENTRICLES OF THE HUMAN BRAIN

Tirkashev Abduvahid Sharof o‘g‘li

Resident Master's student at the Department of Human Anatomy, Samarkand State Medical University

Kamalova Malika Ilkhomovna

Candidate of Medical Sciences, Associate Professor of the Human Anatomy Samarkand State Medical University

Keywords: Morphology, cerebral vessels


Abstract

In modern neuromorphology and neurophysiology, the in-depth study of structures responsible for maintaining the fluid balance of the central nervous system has become increasingly important. In particular, the choroid plexuses located within the brain ventricles play a crucial role in maintaining cerebral homeostasis by producing, circulating, and regulating the resorption of cerebrospinal fluid (CSF). The physiological condition, morphological integrity, and functional activity of these structures are essential for the normal functioning of brain tissues. When the function of the choroid plexuses is disrupted, it leads to changes in CSF circulation and pressure, resulting in the development of severe neurological pathologies such as hydrocephalus, brain edema, and intracranial hypertension. These processes are especially prevalent in elderly individuals. From this perspective, studying the age-related morphological changes of the choroid plexuses is considered one of the important scientific and practical issues.

References

1. Kamalova M.I., Ismoilov O.I. – Morphological changes in the microcirculatory vascular system of the brain in hemorrhagic stroke.

2. Kamalova Malika Ilhomovna, Islamov Shavkat Eriyigitovich, Khaidarov Nodir Kadyrovich. – Morphological features of microvascular tissues in the brain during hemorrhagic stroke. The American Journal of Medical Sciences and Pharmaceutical Research, 2020, 2(10), pp. 53-59.

3. Kamalova M.I., Khaidarov N.K., Islamov Sh.E. – Pathomorphological characteristics of hemorrhagic stroke. Journal of Biomedicine and Practice, 2020, Special Issue, pp. 101-105.

4. Kamalova M.I., Eriyigitovich I.S., Khaydarov N.K. – Morphological changes in cerebral vessels in ischemic stroke. Journal of Biomedicine and Practice, 2020, 6(5).

5. Kamalova M.I., Khaidarov N.K. – Prevention and risk factors of brain infarction (literature review). Journal of Neurology and Neurosurgical Research, 2020, 1(2).

6. Malika K.I., Nodir Kh.K., Shavkat I.E. – Modern risk factors and prevention concepts of brain infarction (literature review). Journal of Neurology and Neurosurgical Research, 2020, 3(1).

7. Khaidarov Nodir Kadyrovich, Shomurodov Kahramon Erkinovich, Kamalova Malika Ilhomovna. – Microscopic examination of postcapillary venules in the brain during hemorrhagic stroke. The American Journal of Medical Sciences and Pharmaceutical Research, 2021, 3(08), pp. 69–73.

8. Agarwal N., Carare R.O. Overview of the anatomy, physiology, and drainage role of brain blood vessels in fluid and solute clearance. Front Neurol., 2021, Vol. 11, Article 611485. DOI: 10.3389/fneur.2020.611485.

9. Louveau A., Smirnov I., Keyes T.J., Eccles J.D., Rouhani S.J., Peske J.D., et al. Structural and functional features of lymphatic vessels in the central nervous system. Nature, 2015, Vol. 523, pp. 337–341. DOI: 10.1038/nature14432.

10. Iadecola C., Nedergaard M. Regulation of brain microcirculation by glial cells. Nat Neurosci., 2007, Vol. 10, pp. 1369–1376. DOI: 10.1038/nn2003.

11. Benkovich I.L. An integrative clinical approach to neurological diseases. Veins Lymphat., 2019, Vol. 8, pp. 49–58. DOI: 10.4081/vl.2019.8470.

12. Agarwal N., Port J.D. Neuroimaging: Anatomy Meets Function. Switzerland: Springer International, 2017, 275 pages. DOI: 10.1007/978-3-319-57427-1.

13. Hill M.A., Nourian Z., Ho I.L., Clifford P.S., Martinez-Lemus L., Meininger G.A. Elastin distribution and structure in small arteries — emphasis on three-dimensional organization. Microcirculation, 2016, Vol. 23, pp. 614–620. DOI: 10.1111/micc.12294.

14. Blinder P., Tsai P.S., Kaufhold J.P., Knutsen P.M., Suhl H., Kleinfeld D. Cortical angiome: interconnected vascular networks and unconventional blood flow patterns. Nat Neurosci., 2013, Vol. 16, pp. 889–897. DOI: 10.1038/nn.3426.

15. MacGregor Sharp M., Bulters D., Brandner S., Holton J., Verma A., Werring D.J., et al. The precise anatomy of perivascular spaces in the human brain: association with enlarged spaces in cerebral amyloid angiopathy. Neuropathol Appl Neurobiol., 2018, Vol. 45, pp. 305–308. DOI: 10.1111/nan.12480.

16. Kravtsova I.L., Nedzved M.K. Morphological features and location of Virchow-Robin spaces in the brain. Problems of Health and Ecology, 2013, Vol. 37, No. 3, pp. 21-27.

17. Wardlaw J.M., Smith E.E., Biessels G.J., Cordonnier C., Fazekas F., Frayne R., et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol., 2013, Vol. 12, pp. 822–838. DOI: 10.1016/S1474-4422(13)70124-8.

18. Hamel E. Perivascular nerves and the regulation of cerebrovascular tone. J. Appl Physiol., 2006, Vol. 100, pp. 1059–1064. DOI: 10.1152/japplphysiol.00954.2005.

19. Fantini S., Sassaroli A., Tgavalekos K.T., Kornbluth J. Brain blood flow and autoregulation: current measurement methods and prospects of non-invasive optical techniques. Neurophotonics, 2016, Vol. 3, Article 031411. DOI: 10.1117/1.NPh.3.3.031411.

20. Reutov V.P., Chertok V.M. New insights into the role of nitric oxide-producing systems in the autonomic nervous system and cerebral vessels. Pacific Medical Journal, 2016, Vol. 64, No. 2, pp. 10-19.

21. Weed L.H. – Studies on cerebrospinal fluid. Part IV: The dual source of cerebrospinal fluid. Journal of Medical Research, September 1914, Vol. 31(1), pp. 93-118.