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Published
2025-04-15
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Articles
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OPTIMIZING MULTIDISCIPLINARY STRATEGIES FOR ALLEVIATING PELVIC DISCOMFORT IN WOMEN WITH PERSISTENT ENDOMETRIAL INFLAMMATION
Tursoatova Sh.M
Samarkand State Medical University
Tursoatova Sh.M
Samarkand State Medical University
Tilyavova S.A
Samarkand State Medical University
Keywords: chronic endometritis, pelvic discomfort
Abstract
Persistent endometrial inflammation, or chronic endometritis (CE), affects 12–25% of women seeking reproductive care, often manifesting as debilitating pelvic discomfort that disrupts daily life. In Uzbekistan, where CE is diagnosed in 10–18% of gynecological patients, fragmented care exacerbates suffering. This randomized controlled trial (RCT) explored innovative multidisciplinary strategies—targeted antibiotics, acupuncture, and mindfulness-based stress reduction (MBSR)—to relieve pelvic discomfort in 160 women aged 20–40 across Tashkent, Fergana, and Bukhara clinics from March 2023 to December 2024. Participants were randomized into four groups: antibiotics, acupuncture, integrated (antibiotics-acupuncture-MBSR), and usual care (control). Primary outcomes were discomfort severity (Pelvic Pain Impact Questionnaire, PPIQ) and inflammatory resolution (biopsy-confirmed). Secondary outcomes included emotional well-being (PHQ-9), fertility potential (ovulatory cycles), and intervention uptake at 8 weeks and 6 months. The integrated group reduced PPIQ scores by 50% (8.5 ± 1.5 to 4.3 ± 1.0, p<0.001) and achieved 80% inflammatory resolution versus 50% in controls (p<0.01). Acupuncture alone eased discomfort by 35%, and antibiotics resolved inflammation in 65%. Emotional well-being improved markedly in the integrated group (PHQ-9 6 ± 2 vs. 12 ± 3 in controls, p<0.001). These results champion a holistic approach, offering Uzbekistan a practical framework to enhance women’s health and informing global CE care.
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